作者： 张黎仙，林堃 （福建省莆田市妇幼保健院新生儿疾病筛查中心；莆田学院附属医院产前诊断中心）

出处： 检验医学与临床 2022

关键词： 珠蛋白生成障碍性贫血；基因诊断；莆田

摘要： 目的 了解莆田市珠蛋白生成障碍性贫血基因变异频率分布情况，并进一步探索莆田市罕见珠蛋白生成障碍性贫血类型、分布情况及遗传特点。方法 对2017年1月至2021年10月来莆田学院附属医院就诊的3 151例疑似珠蛋白生成障碍性贫血者，采用PCR结合导流杂交技术检测珠蛋白生成障碍性贫血基因常见变异类型，对 ...

作者： 姜振宇，黄雁勇，李天瑞，蔡福旭 （西南财经大学；西南交通大学；莆田学院附属医院）

出处： 郑州大学学报(理学版) 2022

关键词： 股票指数预测；时频融合；变分模态分解；时序卷积网络

摘要： 传统的股票指数预测方法是在含噪声、非平稳以及非线性的原始股指序列数据上实施的，这将导致预测精度的下降。为了解决这个问题，提出了一种基于时频融合卷积神经网络的股指预测方法。首先通过引入变分模态分解(VMD)将原始序列数据分解到频域特征上，使得分解后的股指数据具有低信噪比，同时具有更明显的趋势性和平稳性 ...

作者： Shaorui Zheng  ¹, Shuwen Mu  ², Jun Li  ³, Shangming Zhang  ³, Liangfeng Wei  ³, Mingyue Wang  ⁴, Yongjun Xu  ⁵, Shousen Wang  ⁶ （Affiliations ¹ Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China; Department of Neurosurgery, Affiliated Hospital of Putian University, Putian 351100, China. ² Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China. ³ Department of Neurosurgery, The 900th Hospital of Joint Logistic Support Force, Fujian Medical University Fuzong Clinical College, Fuzhou 350025, China. ⁴ Department of Pathology, The 900th Hospital of Joint Logistic Support Force, Fujian Medical University Fuzong Clinical College, Fuzhou 350025, China. ⁵ Laboratory of Basic Medicine, The 900th Hospital of Joint Logistic Support Force, Fujian Medical University Fuzong Clinical College, Fuzhou 350025, China. Electronic address: xuyongjun221123@126.com. ⁶ Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China; Department of Neurosurgery, The 900th Hospital of Joint Logistic Support Force, Fujian Medical University Fuzong Clinical College, Fuzhou 350025, China. Electronic address: wshsen@126.com.）

出处： Brain research 2022

关键词： Cerebral blood flow;Intracranial pressure;Traumatic brain injury.

摘要： Traumatic brain injury (TBI) is a serious public health problem that endangers human health and is divided into primary and secondary injuries. Previo ...

作者： Ling-Feng Zhang  ¹, Yi-Pan Zhang  ¹, Peng-Xing Lin  ¹, Li-Hong Xue  ¹ （Affiliation ¹ Neurology department, The Affiliated Hospital of Putian University, Putian, Fujian, China.）

出处： Pakistan journal of pharmaceutical sciences 2022

摘要： To evaluate the efficacy and safety of sodium oligomannate in the treatment of Alzheimer's disease. Patients with mild-to-moderate AD were randomly di ...

作者： Tian-jiao Song¹;Xiao-hong Lin²;Ping-ting Huang³;Yu-qing Chen³;Li-min Chen³ （¹Department of Emergency, Fujian Provincial Hospital;²Department of Respiratory Medicine, The Affiliated Hospital of Putian University;³Department of Respiratory Medicine, Affiliated Union Hospital of Fujian Medical University）

出处： Scientific Reports 2022

摘要： Lung cancer is the most malignant form of cancer and has the highest morbidity and mortality worldwide. Due to drug resistance, the current chemothera ...

作者： Peng Zhou  ¹, Heng Meng  ², Xiaoyu Liang  ¹, Xiaoyun Lei  ², Jingwen Zhang  ³, Wenjun Bian  ¹, Na He  ¹, Zhijian Lin  ⁴, Xingwang Song  ¹, Weiwen Zhu  ¹, Bin Hu  ¹, Bingmei Li  ¹, Limin Yan  ⁵, Bin Tang  ¹, Tao Su  ¹, Hankui Liu  ⁶, Yong Mao  ⁶, Qiongxiang Zhai  ³, Yonghong Yi  ¹ （Affiliations ¹ Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Department of Neurology, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. ² Department of Neurology, The First Affiliated Hospital of Jinan University, Clinical Neuroscience Institute of Jinan University, Guangzhou, China. ³ Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. ⁴ Department of Neurology, Affiliated Hospital of Putian University, Putian, China. ⁵ Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China. ⁶ BGI-Shenzhen, Shenzhen, China.）

出处： Frontiers in molecular neuroscience 2022

关键词： ADGRV1;audio-visual disorders;febrile seizures;genotype-phenotype correlation;submolecular effect.

摘要： Objective: ADGRV1 gene encodes adhesion G protein-coupled receptor-V1 that is involved in synaptic function. ADGRV1 mutations are associated with audi ...

作者： Yanfang Li¹;Zhiqing Wu¹;Jianlin Shen² （¹Department of Pediatric Surgery, Affiliated Hospital of Putian University, #181 Meiyuan East Road, Putian, 351100, Fujian, China;²Department of Orthopedics, Affiliated Hospital of Putian University, #999 Dongzhen East Road, Putian, 351100, Fujian, China;Corresponding author.）

出处： Regenerative Therapy 2022

关键词： Osteosarcoma;hsa_circ_0000885;miR-16-5p;E2F3;Cancer stem cell

摘要： Introduction: Accumulating evidence has shown that circular RNAs (circRNAs) have indispensable functions during tumor progression by regulating gene e ...

作者： 曾建英^1,2，涂海健³，林仁贵³，陈淑娟³，伦永志^2,4 （¹莆田市第五医院检验科；²莆田学院医学微生态学福建省高校重点实验室；³莆田学院附属医院检验科；⁴消化道恶性肿瘤教育部重点实验室(福建医科大学)）

出处： 中国微生态学杂志 2022

关键词： 基质辅助激光解吸电离飞行时间质谱；耐碳青霉烯类肺炎克雷伯菌；同源性；多位点序列分型；院内感染

摘要： 目的 利用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）筛选碳青霉烯类耐药肺炎克雷伯菌（CRKp）特异性峰，并进行同源性分析。方法 收集30株CRKp临床分离株，采用法国梅里埃VITEK 2 Compact分析仪进行细菌鉴定和药敏试验、利用改良碳青霉烯灭活试验（mCIM）检测碳青霉烯酶 ...

作者： 程学英^1,2，林鹏星¹，薛丽虹¹，刘奔^2,3 （¹莆田学院附属医院神经内科；²莆田学院医学微生态学福建省高校重点实验室；³莆田学院药学与医学技术学院）

出处： 中国微生态学杂志 2022

关键词： 脑脊液；细胞学；化脓性脑膜炎

摘要： 目的 分析成人化脓性脑膜炎患者脑脊液细胞、病原菌等的变化及其关系，为该病的有效诊断、病情监测和针对性治疗提供参考。方法 对我院32例成人化脓性脑膜炎患者用药前后不同时期的脑脊液分别进行常规、生化与细胞学检测，对检测结果进行统计分析。结果 与恢复期比较，患者急性期时脑压、脑脊液白细胞总数与乳酸脱氢酶水 ...

作者： 吴育俊，吴向军，林海滨 （莆田学院附属医院骨科）

出处： 中国微生态学杂志 2022

关键词： 芹菜素；酒精性骨质疏松症；肠道菌群；骨钙代谢

摘要： 目的 探究芹菜素改善酒精性骨质疏松症大鼠肠道菌群、调节骨钙代谢的作用。方法 60只SD健康大鼠采用随机数字表法分为模型组、正常组、常规治疗组以及芹菜素低、中、高剂量组，每组10只。模型组大鼠每天上午用白酒（10 mL/kg）灌胃+生理盐水（10 mL/kg）灌胃；正常组大鼠每天上午用生理盐水（10 ...