作者： Yuanqing Cai^1,2,3;Hongxin Hu^1,2,4,3;Yang Chen^1,2,3;Jiayu Li^1,2;Chaofan Zhang^1,2;Xuhui Yuan^1,2;Wenbo Li^1,2;Changyu Huang⁵;Yiming Lin^1,2;Zeyu Zhang^1,2;Bin Yang⁶;Zida Huang^1,2CA1;Wenming Zhang^1,2CA2;Xinyu Fang^1,2CA3 （¹Department of Orthopaedic Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China;²Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China;³These authors contributed equally to this work.;⁴Department of Orthopaedics, Affiliated Hospital of Putian University, Putian, China;⁵Department of Orthopaedic Surgery, Quanzhou Orthopedic-traumatological Hospital, Quanzhou, China;⁶Department of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China）

出处： Drug Resistance Updates 2026

摘要： Aims In chronic osteomyelitis, the cortical bone serves as the primary site for long-term persistence of Staphylococcus aureus (S. aureus), the presen ...

作者： Jing Yang^1,2;Zhonghui Chen^3,2;Yue Lin¹;Cuiying Lin¹CA1;Fang Luo¹;Bin Qiu¹;Jian Wang¹;Zhenyu Lin¹CA2;Huixing Chen^4,5CA3 （¹Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fujian 350116, PR China;²J.Y. and Z.C. contributed equally to this work. The manuscript was written through the contributions of all authors. All authors have given approval to the final version of the manuscript;³Central Laboratory, Affiliated Hospital of Putian University, Putian University, Putian, Fujian 351100, PR China;⁴Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, PR China;⁵Fujian Medical University Cancer Center, Fuzhou, Fujian 350000, PR China）

出处： Sensors and Actuators B: Chemical 2026

摘要： Elevated hyaluronidase (HAase) concentration has been found in the urine samples of the patients with bladder cancer and development of simple but sen ...

作者： 翁鑫泽¹，黄臣¹，赖颖真¹，尹戈¹，雷奕宣¹，许志强² （¹厦门医学院口腔医学系 口腔生物材料福建省高校工程研究中心, 厦门；²莆田学院附属医院口腔科, 莆田）

出处： 中华口腔医学杂志 2025

关键词： 钛；牙种植；巨噬细胞；破骨分化；仿骨单位；同心圆形微沟槽

摘要： 目的探讨钛表面仿骨单位同心圆形微沟槽结构尺寸对巨噬细胞破骨分化的影响, 为种植体表面改性提供参考。方法选择表面溅射钛的硅片制作对照组(表面光滑的试件)与4个同心圆组表面制作最大直径为200 μm, 最小直径为20 μm, 同心圆间隔为10或30 μm, 微沟槽宽度为10或30 μm, 微沟槽深度为5 ...

作者： Xu Chen  ^{1   2}, Yanyan Zhang  ³, Zhibo Deng  ^{1   4}, Chao Song  ^{1   4}, Linhai Yang  ¹, Rongsheng Zhang  ¹, Peng Zhang  ¹, Yu Xiu  ⁵, Yibin Su  ⁵, Jun Luo  ^{1   4}, Jie Xu  ^{1   4}, Hanhao Dai  ^{1   4} （Affiliations ¹ Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. ² Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Putian University, Putian, China. ³ Department of Clinical Laboratory, The Affiliated Hospital of Putian University, Putian, China. ⁴ Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. ⁵ College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.）

出处： Journal of cachexia, sarcopenia and muscle 2025

关键词： PI3K/AKT/mTOR pathway;keratocan;osteoporosis;osteosarcopenia;sarcopenia.

摘要： Background: Osteosarcopenia refers to the co-occurrence of osteoporosis and sarcopenia, which are characterized by progressive bone density and muscle ...

作者： Yang Yu-Ting ^{#  1}, Chen Li-Xiang ^{#  1   2}, Yao Miao  ¹, Yang Yong-Wei  ¹, Lin Ting  ³ （Affiliations ¹ The School of Nursing, Fujian Medical University, No. 1 Xuefu North Road, New University District, Fuzhou, Fujian, 350122, China. ² The Affiliated Hospital of Putian University, No. 181 Meiyuan East Road, Putian, Fujian, China. ³ The School of Nursing, Fujian Medical University, No. 1 Xuefu North Road, New University District, Fuzhou, Fujian, 350122, China. lt22862125@fjmu.edu.cn.）

出处： BMC public health 2025

关键词： Child;Problem behaviour;Screen time.

摘要： Background: Screen time encompasses activities conducted on digital devices, including traditional devices such as televisions and computers, as well ...

作者： 范金清^1,2，李雅茹²，赵文琪³，张思琪²，温俊斌²，伦永志³ （¹莆田学院附属医院检验科；²莆田学院药学与医学技术学院医学检验系；³泉州医学高等专科学校感染性疾病筛检与防控福建省高校重点实验室）

出处： 中国微生态学杂志 2025

关键词： 植物乳杆菌SAL；L-谷氨酸；合生元；氧化应激；肠道屏障

摘要： 目的 观察植物乳杆菌SAL-L型谷氨酸合生元对氧化应激损伤模型小鼠的缓解作用并探究其作用机制。方法 通过腹腔注射D-半乳糖（D-gal）建立氧化应激小鼠模型，随后将小鼠随机分为正常对照组、模型对照组、植物乳杆菌SAL组、L-谷氨酸组和植物乳杆菌SAL-L型谷氨酸合生元组。连续灌胃给药4周后，收集小鼠 ...

作者： Yucai Jiang  ¹, Guolin Alexander Wen  ^{2   3} （Affiliations ¹ Department of Pharmacy, Affiliated Hospital of Putian University, Putian, Fujian, China. ² Department of Pharmacy, Dana-Farber Cancer Institute, Boston, MA, United States. ³ Faculty of Synapse Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.）

出处： Frontiers in pharmacology 2025

关键词： cell-free DNA;circulating tumor DNA;next-generation sequencing;pharmacogenomics;precision medicine;tumor-agnostic drug.

摘要： Background/objectives: This article reviews some key emerging pharmacogenomic topics in oncology pharmacy practice. Methods: Publications selected to ...

作者： Yongping Shi  ¹, Mi Jiang  ¹, Wenzhong Zhu  ¹, Ke Chang  ¹, Xukai Cheng  ¹, Haijun Bao  ¹, Zuojie Peng  ¹, Yuan Hu  ¹, Chao Li  ¹, Feifei Fang  ¹, Jia Song  ¹, Chenxing Jian  ², Jinhuang Chen  ³, Xiaogang Shu  ⁴ （Affiliations ¹ Department of ganstroenterology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, China. ² Department of anorectal surgery, Affiliated hospital of Putian University, China. ³ Department of emergency surgery, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, China. ⁴ Department of ganstroenterology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: sxg678@hust.edu.cn.）

出处： Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025

关键词： ABC transporters;Immunosuppression;butyric acid;gut microbiota;lipid metabolism.

摘要： Immunosuppression often leads to drastic metabolic, hormonal, and physiological disorders. Changes in the gut microbiota are believed to be one of the ...

作者： 黄世杰，范梦颖，彭凯明，闫万璞，陈博扬，王武，杨天宝，陈克能，康明强，谢金标 （莆田学院附属医院胸心外科一区；北京市癌症与转化研究重点实验室；北京大学肿瘤医院胸外一科；福建医科大学附属协和医院胸外二科；国家分子肿瘤学重点实验室）

出处： 中国肺癌杂志 2025

关键词： 肺肿瘤；新辅助靶向治疗；表皮生长因子受体；主要病理缓解

摘要： 背景与目的 我国非小细胞肺癌（non-small cell lung cancer, NSCLC）患者中表皮生长因子受体（epidermal growth factor receptor, EGFR）突变占比较高，然而这部分患者当前的新辅助治疗方案缺乏明显获益。本研究旨在通过分析新辅助靶向治疗在EG ...

作者： Liumin Yu ¹, Guanghui Xu ¹, Zhanfei Chen ¹, Kun Lin ², Jinqiu Li ³, Hua Lin ⁴ （Affiliations ¹ Department of Laboratory Medicine, the Affiliated Hospital of Putian University, Putian University, No.999 Dongzhen East Road, Licheng District, Putian, Fujian, 351100, China. ² Prenatal Diagnosis Center, the Affiliated Hospital of Putian University, Putian University, Putian, 351100, China. ³ Central Laboratory, the Affiliated Hospital of Putian University, Putian University, Putian, 351100, China. ⁴ Department of Laboratory Medicine, the Affiliated Hospital of Putian University, Putian University, No.999 Dongzhen East Road, Licheng District, Putian, Fujian, 351100, China. linhua_28@126.com.）

出处： Annals of hematology 2025

关键词： Epidemiology;Gene mutation;Genotype;Infertility;Thalassemia.

摘要： Thalassemia is one of the most prevalent inherited hemolytic diseases. This study aimed to characterize thalassemia mutations and provide an epidemiol ...