作者： 翁鑫泽¹，黄臣¹，赖颖真¹，尹戈¹，雷奕宣¹，许志强² （¹厦门医学院口腔医学系 口腔生物材料福建省高校工程研究中心, 厦门；²莆田学院附属医院口腔科, 莆田）

出处： 中华口腔医学杂志 2025

关键词： 钛；牙种植；巨噬细胞；破骨分化；仿骨单位；同心圆形微沟槽

摘要： 目的探讨钛表面仿骨单位同心圆形微沟槽结构尺寸对巨噬细胞破骨分化的影响, 为种植体表面改性提供参考。方法选择表面溅射钛的硅片制作对照组(表面光滑的试件)与4个同心圆组表面制作最大直径为200 μm, 最小直径为20 μm, 同心圆间隔为10或30 μm, 微沟槽宽度为10或30 μm, 微沟槽深度为5 ...

作者： Xu Chen  ^{1   2}, Yanyan Zhang  ³, Zhibo Deng  ^{1   4}, Chao Song  ^{1   4}, Linhai Yang  ¹, Rongsheng Zhang  ¹, Peng Zhang  ¹, Yu Xiu  ⁵, Yibin Su  ⁵, Jun Luo  ^{1   4}, Jie Xu  ^{1   4}, Hanhao Dai  ^{1   4} （Affiliations ¹ Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. ² Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Putian University, Putian, China. ³ Department of Clinical Laboratory, The Affiliated Hospital of Putian University, Putian, China. ⁴ Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. ⁵ College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.）

出处： Journal of cachexia, sarcopenia and muscle 2025

关键词： PI3K/AKT/mTOR pathway;keratocan;osteoporosis;osteosarcopenia;sarcopenia.

摘要： Background: Osteosarcopenia refers to the co-occurrence of osteoporosis and sarcopenia, which are characterized by progressive bone density and muscle ...

作者： Yang Yu-Ting ^{#  1}, Chen Li-Xiang ^{#  1   2}, Yao Miao  ¹, Yang Yong-Wei  ¹, Lin Ting  ³ （Affiliations ¹ The School of Nursing, Fujian Medical University, No. 1 Xuefu North Road, New University District, Fuzhou, Fujian, 350122, China. ² The Affiliated Hospital of Putian University, No. 181 Meiyuan East Road, Putian, Fujian, China. ³ The School of Nursing, Fujian Medical University, No. 1 Xuefu North Road, New University District, Fuzhou, Fujian, 350122, China. lt22862125@fjmu.edu.cn.）

出处： BMC public health 2025

关键词： Child;Problem behaviour;Screen time.

摘要： Background: Screen time encompasses activities conducted on digital devices, including traditional devices such as televisions and computers, as well ...

作者： 范金清^1,2，李雅茹²，赵文琪³，张思琪²，温俊斌²，伦永志³ （¹莆田学院附属医院检验科；²莆田学院药学与医学技术学院医学检验系；³泉州医学高等专科学校感染性疾病筛检与防控福建省高校重点实验室）

出处： 中国微生态学杂志 2025

关键词： 植物乳杆菌SAL；L-谷氨酸；合生元；氧化应激；肠道屏障

摘要： 目的 观察植物乳杆菌SAL-L型谷氨酸合生元对氧化应激损伤模型小鼠的缓解作用并探究其作用机制。方法 通过腹腔注射D-半乳糖（D-gal）建立氧化应激小鼠模型，随后将小鼠随机分为正常对照组、模型对照组、植物乳杆菌SAL组、L-谷氨酸组和植物乳杆菌SAL-L型谷氨酸合生元组。连续灌胃给药4周后，收集小鼠 ...

作者： Yucai Jiang  ¹, Guolin Alexander Wen  ^{2   3} （Affiliations ¹ Department of Pharmacy, Affiliated Hospital of Putian University, Putian, Fujian, China. ² Department of Pharmacy, Dana-Farber Cancer Institute, Boston, MA, United States. ³ Faculty of Synapse Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.）

出处： Frontiers in pharmacology 2025

关键词： cell-free DNA;circulating tumor DNA;next-generation sequencing;pharmacogenomics;precision medicine;tumor-agnostic drug.

摘要： Background/objectives: This article reviews some key emerging pharmacogenomic topics in oncology pharmacy practice. Methods: Publications selected to ...

作者： Yongping Shi  ¹, Mi Jiang  ¹, Wenzhong Zhu  ¹, Ke Chang  ¹, Xukai Cheng  ¹, Haijun Bao  ¹, Zuojie Peng  ¹, Yuan Hu  ¹, Chao Li  ¹, Feifei Fang  ¹, Jia Song  ¹, Chenxing Jian  ², Jinhuang Chen  ³, Xiaogang Shu  ⁴ （Affiliations ¹ Department of ganstroenterology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, China. ² Department of anorectal surgery, Affiliated hospital of Putian University, China. ³ Department of emergency surgery, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, China. ⁴ Department of ganstroenterology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: sxg678@hust.edu.cn.）

出处： Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025

关键词： ABC transporters;Immunosuppression;butyric acid;gut microbiota;lipid metabolism.

摘要： Immunosuppression often leads to drastic metabolic, hormonal, and physiological disorders. Changes in the gut microbiota are believed to be one of the ...

作者： Xuan Lin¹;Kun Lin²;Yue Lai³;Qingping Peng⁴;Miao Xu⁵;Yiting Xu⁶;Jialin Yang⁶;Huan Liu⁷;Jianlin Shen⁸ （¹Central Laboratory, Affiliated Hospital of Putian University, Putian, Fujian Province 351100, China;Department of Environmental and Biological Engineering, Putian University, Putian, Fujian Province 351100, China;²Department of Laboratory Medicine, the Affiliated Hospital of Putian University, Putian University, Putian 351100, China;³The First Clinical Medical School, Guangdong Medical University, Zhanjiang, Guangdong Province 524002, China;⁴Collage of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan Province 646000, China;⁵School of Basic Medicine, Fujian Medical University, Fuzhou, Fujian Province 350100, China;⁶Department of Clinical Medicine, Putian University, Putian, Fujian Province 351100, China;⁷Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan Province 646000, China;Corresponding author.;⁸Central Laboratory, Affiliated Hospital of Putian University, Putian, Fujian Province 351100, China;Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian Province 351100, China;Corresponding author at: Central Laboratory, Affiliated Hospital of Putian University, Putian, Fujian Province 351100, China.）

出处： Ecotoxicology and Environmental Safety 2025

关键词： ATBC;Network toxicology;Molecular docking;Bone metabolism

摘要： This study aims to elucidate the intricate effects of Acetyl tributyl citrate (ATBC) on bone metabolism, disentangling the underlying molecular mechan ...

作者： Xi Chen^{1 na1};Meinv Huang^{1 na1};Yi Chen¹;Haishan Xu² & …Meifang Wu¹ （¹Department of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, China;²Department of Nephrology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, China）

出处： Heart Failure Reviews 2025

关键词： Mineralocorticoid receptor;Mineralocorticoid receptor antagonists;Heart failure with preserved ejection fraction;Phenotype;Finerenone

摘要： The mineralocorticoid receptor (MR), part of the steroid hormone receptor subfamily within nuclear hormone receptors, is found in the kidney and vario ...

作者： Yanyan Zhang  ¹, Qin Weng  ², Zhibo Deng  ³, Huaizhi Zhang  ², Jianhui Dai  ², Xu Chen  ^{2   3} （Affiliations ¹ Department of Clinical Laboratory, The Affiliated Hospital of Putian University, Putian, China. ² Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Putian University, Putian, China. ³ Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.）

出处： Medicine 2025

摘要： Observational epidemiological studies indicate a higher fracture incidence in rheumatoid arthritis (RA) patients compared to the general population. H ...

作者： Yanqin Xu MD^1,2;Yinxin Wu MD^1,2;Wanyin Deng MD¹;Xianbin Guo MD¹;Pingting Gao MD³;Shijie Yang MD¹;Yahua Chen MD⁴;Pinghong Zhou MD³;Wei Liang MD¹CA （¹Department of Digestive Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China;²Drs Xu and Wu contributed equally to this article.;³Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Affiliated with Fudan University, Shanghai, China;⁴Department of Gastroenterology, Affiliated Hospital of Putian University, Putian, China）

出处： Gastrointestinal Endoscopy 2025

摘要： Background and Aims Deep endotracheal intubation (DET) has been proposed to improve cervical esophageal endoscopic submucosal dissection (ESD) because ...