作者： Chunyong Xia ^{#  1}, Zhijing Liu ^{#  2}, Jie Liu  ¹, Li Lin  ³, Maohua Chen  ⁴ （Affiliations ¹ Department of Pharmacy, Chongqing university jiangjin hospital, Jiang jin 402260, Chongqing, China. ² Department of Pharmacy, Affiliated Hospital of Putian University, Pu Tian 351100, Fujian, China. ³ Department of Medical Oncology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, NO.134 Dongjie Street, Fuzhou, 350001, Fujian, China. linlizzu@163.com. ⁴ Department of Pharmacy, Pingtan Comprehensive Experimental Area Hospital, Pingtan Comprehensive Experimental Area, Fujian, 350400, PR China. mhcptyy@126.com.）

出处： Investigational new drugs 2024

关键词： Adverse events;Efficacy;FAERS;Prostate cancer;Relugolix;Safety.

摘要： Background: Relugolix has been used to treat advanced prostate cancer. This study assessed adverse events (AEs) associated with relugolix from the US ...

作者： 吴仕文¹，郑新龙¹，徐贻佺¹，徐海鹏¹，张龙凤¹，刘涛²，李冰³，王贻军⁴，吴敬勋⁵，吴辉塔⁶，陈鹏涛⁷，杨红奎⁸，林根¹ （¹福建医科大学肿瘤临床医学院福建省肿瘤医院胸部肿瘤内科；²漳州正兴医院肿瘤内科；³莆田学院附属医院肿瘤内科；⁴福建医科大学附属漳州市医院肿瘤内科；⁵厦门大学附属第一医院肿瘤内科；⁶厦门大学附属中山医院肿瘤科；⁷福鼎市医院肿瘤内科；⁸泉州市第一医院肿瘤内科）

出处： 中华实用诊断与治疗杂志 2024

关键词： 肺腺鳞癌；非小细胞肺癌；化疗；培美曲塞；紫杉醇类；吉西他滨

摘要： 目的 比较晚期肺腺鳞癌患者采用培美曲塞、紫杉醇类/吉西他滨为主的一线化疗方案治疗的效果，探讨对患者生存期的影响。方法 2012年1月—2022年4月福建省肿瘤医院、漳州正兴医院、莆田学院附属医院、福建医科大学附属漳州市医院、厦门大学附属第一医院、厦门大学附属中山医院、福鼎市医院、泉州市第一医院诊治晚 ...

作者： Bing Li;|Guoliang Zhang;|Xuejie Xu （Affiliations ¹ Department of Medical Oncology, The Affiliated Hospital of Putian University, No. 999 Dongzhen Road, Licheng District, Putian, Fujian, 351100, China. ² Department of Thyroid Surgery, The Affiliated Hospital of Putian University, Fujian, 351100, China. ³ Department of Medical Oncology, The Affiliated Hospital of Putian University, No. 999 Dongzhen Road, Licheng District, Putian, Fujian, 351100, China. xuxuejie_xj@163.com.）

出处： BMC gastroenterology 2023

关键词： APC mutation;Immune cell infiltration;Immunotherapy;Tumor mutation burden;colon cancer.

摘要： Objective: APC (adenomatous polyposis coli) gene mutation is a central initialization in colon cancer tumorigenesis. However, the connection between A ...

作者： Bing Li  ¹, Xuejie Xu  ¹, Linlin Zheng  ¹, Xiaojie Jiang  ², Jing Lin  ³, Guoliang Zhang  ⁴ （Affiliations ¹ Department of Medical Oncology, the Affiliated Hospital of Putian University, Putian, 351100, Fujian province, China. ² Department of Hepatobiliary Surgery, the Affiliated Hospital of Putian University, Putian, 351100, Fujian province, China. ³ Department of Pathology, the Affiliated Hospital of Putian University, Putian, 351100, Fujian province, China. ⁴ Department of Thyroid Surgery, the Affiliated Hospital of Putian University, Putian, 351100, Fujian province, China. 124236332@qq.com.）

出处： Molecular biology reports 2023

关键词： Cisplatin resistance;Ovarian cancer;hMSH2;miR-590-5p.

摘要： Objective: The mechanisms of ovarian cancer generate chemotherapy resistance are still unclear. This study aimed to explore the role of microRNA (miR) ...

作者： Guoliang Zhang¹;Bing Li²;Yuanmei Lin¹ （1 Department of Thyroid Surgery, Affiliated Hospital of Putian University, Putian, China. 2 Department of Medical Oncology, Affiliated Hospital of Putian University, Putian, China.）

出处： Frontiers in oncology 2022

关键词： ITGA3;biomarker;integrins;papillary thyroid carcinoma (PTC);prognosis;recurrence;thyroid cancer.

摘要： Objective: To investigate the expression of ITGA3 and its association with clinical outcomes in papillary thyroid carcinoma (PTC). Methods: The expres ...

作者： 方利军，唐菊素，方馥荔 （莆田学院附属医院护理部；莆田学院附属医院肿瘤内科）

出处： 中外医疗 2022

关键词： 叙事护理；胃癌晚期；心理弹性；悲伤程度

摘要： 目的 探讨胃癌晚期患者进行叙事护理对患者的心理弹性以及悲伤程度的影响。方法 方便选取2019 年7 月—2021 年7 月该院收治的胃癌晚期患者147 例作为研究对象，按照随机法将其分为观察组（74 例）和一般组（73 例），一般组主要对患者进行常规护理，观察组在一般组的基础上进行叙事护理，对比两组 ...

作者： Tingting Huang  ^{1   2}, Jiwei Li  ³, Xinli Liu  ¹, Bingbing Shi  ⁴, Shiqin Li  ⁵, Han-Xiang An  ¹ （Affiliations ¹ Department of Medical Oncology, Xiang'an Hospital of Xiamen University, Xiamen, China. ² Department of Medical Oncology, Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine, Xiamen, China. ³ Department of Respiratory, Critical Care and Sleep Medicine, Xiang'an Hospital of Xiamen University, Xiamen, China. ⁴ Department of Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, China. ⁵ Department of Gastroenterology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.）

出处： Frontiers in immunology 2022

关键词： SCF complex;difference;immune infiltration;pan-cancer;prognosis;ring-finger proteins.

摘要： Background: The SCF (Skp1-cullin-F-box proteins) complex is the largest family of E3 ubiquitin ligases that mediate multiple specific substrate protei ...

作者： 方馥荔 （莆田学院附属医院肿瘤内科）

出处： 中外医疗 2022

关键词： 结构式家庭护理指导；乳腺癌；化疗；癌性疲乏；生活质量

摘要： 目的探讨结构式家庭护理指导对乳腺癌化疗患者癌性疲乏及生活质量的影响。方法 随机选择该院2020年1—12月期间收治的乳腺癌化疗患者80例，以随机数表法将其分为观察组与对照组，各40例，对照组患者应用常规护理，观察组在对照组基础上联合结构式家庭护理指导，比较两组护理效果。结果 观察组患者癌性疲乏评分为 ...

作者： Boyang Chen;Yafeng Wang;Weifeng Tang;Yu Chen;Chao Liu;Mingqiang Kang;Jinbiao Xie （¹Department of Cardiothoracic Surgery, The Affiliated Hospital of Putian University, 351100, Putian, Fujian Province, China;²Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China;³Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China;⁴Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China;⁵Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China;⁶Department of Thoracic Surgery, Fujian Medical University Union Hospital, 350001, Fuzhou, Fujian Province, China）

出处： BMC Medical Genomics 2022

关键词： PPARγ;PPARGC1A;PPARGC1B;Variant;SNVs;Gastric cancer

摘要： Purpose Previous studies showed that peroxisome proliferator-activated receptor gamma ( PPARγ ) and PPARγ coactivator1 family ( PPARGC1A and PPARGC1B ...

作者： Chen, Boyang;Wang, Yafeng;Tang, Weifeng;Chen, Yu;Liu, Chao;Kang, Mingqiang;Xie, Jinbiao （¹Department of Cardiothoracic Surgery, The Affiliated Hospital of Putian University, 351100, Putian, Fujian Province, China ²Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China ³Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China ⁴Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China ⁵Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China ⁶Department of Thoracic Surgery, Fujian Medical University Union Hospital, 350001, Fuzhou, Fujian Province, China）

出处： BMC Medical Genomics 2022

关键词： Gastric cancer;PPARγ;PPARGC1A;PPARGC1B;SNVs;Variant

摘要： Purpose: Previous studies showed that peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator1 family (PPARGC1A and PPARGC1B) g ...