作者： 赖越¹，林轩²，徐淼³，刘欢⁴，沈剑粦⁵，黄文华^1,6 （¹广东医科大学第一临床医学院；²莆田学院环境与生物工程学院；³福建医科大学基础医学院；⁴西南医科大学附属中医医院骨科；⁵莆田学院附属医院中心实验室；⁶南方医科大学基础医学院人体解剖学国家重点学科,广东省数字医学与生物力学重点实验室,广东省医学 3D 打印应用转化工程技术研究中心）

出处： 中国组织工程研究 2025

关键词： 骨质疏松；海洋中药；数据挖掘；网络药理学；分子对接

摘要： 背景：海洋中药为治疗骨质疏松提供了一种潜在有效且不易产生不良反应的方法。目的：应用数据挖掘和网络药理学方法分析并探讨中医临床治疗骨质疏松的用药规律及作用机制。方法：采用数据挖掘和网络药理学方法，对国家知识产权局批准的治疗骨质疏松的海洋中药专利处方进行用药模式和作用机制研究，并特别关注这些处方中的核心 ...

作者： 曾庆煌，魏凤芳，许金霞，郑丽平，林灵木，肖旭 （莆田学院附属医院儿科）

出处： 中国病原生物学杂志 2025

关键词： 癫痫；肠道菌群失衡；影响因素

摘要： 目的分析癫痫患儿肠道菌群失衡状况及影响因素。方法将本院2020年9月~2023年8月期间收治的96例癫痫患儿设为观察组,另选取同期92名健康儿童为对照组。根据肠道菌群是否失衡将观察组分为未失衡组(n=45)和失衡组(n=51)。癫痫患儿肠道菌群失衡的影响因素采用多因素Logistic回归分析。绍结果 ...

作者： Yanqin Xu MD^1,2;Yinxin Wu MD^1,2;Wanyin Deng MD¹;Xianbin Guo MD¹;Pingting Gao MD³;Shijie Yang MD¹;Yahua Chen MD⁴;Pinghong Zhou MD³;Wei Liang MD¹CA （¹Department of Digestive Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China;²Drs Xu and Wu contributed equally to this article.;³Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Affiliated with Fudan University, Shanghai, China;⁴Department of Gastroenterology, Affiliated Hospital of Putian University, Putian, China）

出处： Gastrointestinal Endoscopy 2025

摘要： Background and Aims Deep endotracheal intubation (DET) has been proposed to improve cervical esophageal endoscopic submucosal dissection (ESD) because ...

作者： Zhongdong Xie¹;Hanbin Lin²;Yuecheng Wu³;Yanan Yu⁴;Xintong Liu⁵;Yating Zheng⁶;Xiaojie Wang¹;Jiashu Wu⁷;Meifang Xu⁸;Yuting Han³;Qiongying Zhang⁹;Yu Deng¹;Lin Lin⁸;Yan Linzhu¹;Li Qingyun¹;Xinjian Lin³;Ying Huang¹;Pan Chi¹ （¹Department of Colorectal Surgery, Union Hospital, Fujian Medical University;²Central Laboratory, Affiliated Hospital of Putian University;³Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education;⁴Guilin Medical University;⁵Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University;⁶Department of Colorectal Surgery, The First Affiliated Hospital of Wenzhou Medical University;⁷Department of Science and Technology, The First Affiliated Hospital of Wenzhou Medical University;⁸Department of Pathology, Union Hospital, Fujian Medical University;⁹Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University）

出处： Cell Death and Disease 2025

摘要： Metastasis is a major challenge for colorectal cancer (CRC) treatment. In this study, we identified autophagy activation as a prognostic indicator in ...

作者： Jia Xu^1,2;Qiuhui Wang^1,3,2;Yishen Hu^1,3;Qingfeng Guo¹;Hu Zhu⁴;Honglin Wang⁵CA1;Hongxin Hu⁶CA2;Shouan Wang¹CA3;Jianbin Ye^1,3CA4 （¹Putian University, School of Basic Medicine Science, Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian City, Fujian Province 351100, China;²contribute equally to the study.;³Fujian Province, 351100, China Fujian Medical University, School of Pharmacy, Fuzhou City, Fujian Province 350004, China;⁴Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Engineering Research Center of Industrial Biocatalysis, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;⁵Department of Orthopedic Surgery, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing 402360, China;⁶The Affiliated Hospital of Putian University, Putian City, Fujian Province 351100, China）

出处： International Journal of Biological Macromolecules 2025

摘要： Scutellaria baicalensis extracts (SBACs), a herb that contains a variety of bioactive flavonoids like baicalein and baicalin, which impart antibacteri ...

作者： Lan-Ting Huang  ¹, Xiao-Yan Zheng  ², Zhi-Hong Zhang  ², Hong-Yan Zheng  ³, Xin Wei  ⁴, Ji-Yan Yang  ⁵, Li-Hua Zhang  ⁶, Xiu-Qin Lu  ⁷, Ying-Qing Yang  ⁸, Jin-Xia Lin  ⁹, Chun-Mei Zhang  ¹⁰, Li-Ping Luo  ¹¹, Dong-Hua Jiang  ¹², Shao-Hua Huang  ¹³, Xiu-Bi Huang  ¹⁴, Yue-Mei Zhan  ¹⁵, Wen-Zhu Xu  ¹⁶, Wei Han  ^{17   18}, Fu-Yuan Hong  ¹⁹ （Affiliations ¹ Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. lanne_huang@foxmail.com. ² Department of Blood Purification, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. ³ Department of Blood Purification, Renhe Hospital of Hubei Three Gorges University, Yichang, Hubei, China. ⁴ Department of Blood Purification, Xinjiang Changji Hui Autonomous Prefecture Hospital of Traditional Chinese Medicine, Changji, Xinjiang, China. ⁵ Department of Blood Purification, Pengyang People's Hospital of Ningxia Hui Autonomous Region, Pengyang, Ningxia, China. ⁶ Department of Blood Purification, Fuzhou First Hospital, Fuzhou, Fujian, China. ⁷ Department of Blood Purification, Fuzhou General Hospital, Fuzhou, Fujian, China. ⁸ Department of Blood Purification, Affiliated Hospital of Putian University, Putian, Fujian, China. ⁹ Department of Blood Purification, Quanzhou First Hospital, Quanzhou, Fujian, China. ¹⁰ Department of Blood Purification, Wuyishan Municipal Hospital, Wuyishan, Fujian, China. ¹¹ Department of Blood Purification, Nanping People's Hospital, Nanping, Fujian, China. ¹² Department of Blood Purification, Sanming Second Hospital, Sanming, Fujian, China. ¹³ Department of Blood Purification, Sanming First Hospital, Sanming, Fujian, China. ¹⁴ Department of Blood Purification, Zhangzhou Hospital, Zhangzhou, Fujian, China. ¹⁵ Department of Blood Purification, Longyan First Hospital, Longyan, Fujian, China. ¹⁶ Department of Blood Purification, Ningde Mindong Hospital, Mindong, Fujian, China. ¹⁷ Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. ¹⁸ Department of Blood Purification, Xiamen Zhongshan Hospital, Xiameng, Fujian, China. ¹⁹ Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. hongdoc@163.com.）

出处： Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2025

作者： X Z Weng  ¹, C Huang  ¹, Y Z Lai  ¹, G Yin  ¹, Y X Lei  ¹, Z Q Xu  ² （Affiliations ¹ Department of Stomatology, Xiamen Medical College, Engineering Research Center of Stomatological Biomaterials, Fujian Province University, Xiamen 361023, China. ² Department of Stomatology, Affiliated Hospital of Putian University, Putian 351106, China.）

出处： Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 2025

摘要： Objective: To investigate the effect of the sizes of osteon-like concentric microgroove structures on the osteoclastic differentiation of macrophages ...

作者： Xu Chen  ^{1   2}, Yanyan Zhang  ³, Zhibo Deng  ^{1   4}, Chao Song  ^{1   4}, Linhai Yang  ¹, Rongsheng Zhang  ¹, Peng Zhang  ¹, Yu Xiu  ⁵, Yibin Su  ⁵, Jun Luo  ^{1   4}, Jie Xu  ^{1   4}, Hanhao Dai  ^{1   4} （Affiliations ¹ Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. ² Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Putian University, Putian, China. ³ Department of Clinical Laboratory, The Affiliated Hospital of Putian University, Putian, China. ⁴ Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. ⁵ College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.）

出处： Journal of cachexia, sarcopenia and muscle 2025

关键词： PI3K/AKT/mTOR pathway;keratocan;osteoporosis;osteosarcopenia;sarcopenia.

摘要： Background: Osteosarcopenia refers to the co-occurrence of osteoporosis and sarcopenia, which are characterized by progressive bone density and muscle ...

作者： Yang Yu-Ting ^{#  1}, Chen Li-Xiang ^{#  1   2}, Yao Miao  ¹, Yang Yong-Wei  ¹, Lin Ting  ³ （Affiliations ¹ The School of Nursing, Fujian Medical University, No. 1 Xuefu North Road, New University District, Fuzhou, Fujian, 350122, China. ² The Affiliated Hospital of Putian University, No. 181 Meiyuan East Road, Putian, Fujian, China. ³ The School of Nursing, Fujian Medical University, No. 1 Xuefu North Road, New University District, Fuzhou, Fujian, 350122, China. lt22862125@fjmu.edu.cn.）

出处： BMC public health 2025

关键词： Child;Problem behaviour;Screen time.

摘要： Background: Screen time encompasses activities conducted on digital devices, including traditional devices such as televisions and computers, as well ...

作者： Xudong Wang  ¹, Xingxiu Lu  ², Faming Zheng  ³, Kun Lin  ⁴, Minjuan Liao  ⁵, Yi Dong  ⁶, Tiantian Chen  ⁷, Ying He  ¹, Mei Lu  ^{8   9}, Jing Chen  ^{9   10}, Yanfang Li  ¹, Yulin Zhou  ¹ （Affiliations ¹ Xiamen Newborn Screening Center, Department of Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361102, China. ² United Diagnostic and Research Center for Clinical Genetics, School of Public Health, Xiamen University, Xiamen 361100, China. ³ Center of Neonatal Disease Screening, Quanzhou Maternity and Children's Hospital, Quanzhou 362000, China. ⁴ Prenatal Diagnosis Center, The Affiliated Hospital of Putian University, Putian University, Putian 351100, China. ⁵ Longyan Newborn Screening Center, The First Hospital of Longyan City, Longyan 364099, China. ⁶ Screening Center of Neonatal Genetic Metabolic Disease, Ningde Maternity and Child Health Care Hospital, Ningde 352100, China. ⁷ Zhangzhou Newborn Screening Center, Zhangzhou Maternity and Child Care Hospital, Zhangzhou 363000, China. ⁸ Department of Pediatric Endocrinology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361102, China. ⁹ Department of Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361102, China. ¹⁰ Department of Child Health, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361102, China.）

出处： International journal of neonatal screening 2025

关键词： combined screening strategy;congenital adrenal hyperplasia;long-read sequencing;newborn screening;second-tier screening.

摘要： Long-read sequencing (LRS) provides comprehensive genetic information, but research of LRS applied to congenital adrenal hyperplasia (CAH) newborn scr ...