作者： 赖越¹，林轩²，徐淼³，刘欢⁴，沈剑粦⁵，黄文华^1,6 （¹广东医科大学第一临床医学院；²莆田学院环境与生物工程学院；³福建医科大学基础医学院；⁴西南医科大学附属中医医院骨科；⁵莆田学院附属医院中心实验室；⁶南方医科大学基础医学院人体解剖学国家重点学科,广东省数字医学与生物力学重点实验室,广东省医学 3D 打印应用转化工程技术研究中心）

出处： 中国组织工程研究 2025

关键词： 骨质疏松；海洋中药；数据挖掘；网络药理学；分子对接

摘要： 背景：海洋中药为治疗骨质疏松提供了一种潜在有效且不易产生不良反应的方法。目的：应用数据挖掘和网络药理学方法分析并探讨中医临床治疗骨质疏松的用药规律及作用机制。方法：采用数据挖掘和网络药理学方法，对国家知识产权局批准的治疗骨质疏松的海洋中药专利处方进行用药模式和作用机制研究，并特别关注这些处方中的核心 ...

作者： 曾庆煌，魏凤芳，许金霞，郑丽平，林灵木，肖旭 （莆田学院附属医院儿科）

出处： 中国病原生物学杂志 2025

关键词： 癫痫；肠道菌群失衡；影响因素

摘要： 目的分析癫痫患儿肠道菌群失衡状况及影响因素。方法将本院2020年9月~2023年8月期间收治的96例癫痫患儿设为观察组,另选取同期92名健康儿童为对照组。根据肠道菌群是否失衡将观察组分为未失衡组(n=45)和失衡组(n=51)。癫痫患儿肠道菌群失衡的影响因素采用多因素Logistic回归分析。绍结果 ...

作者： Lan-Ting Huang  ¹, Xiao-Yan Zheng  ², Zhi-Hong Zhang  ², Hong-Yan Zheng  ³, Xin Wei  ⁴, Ji-Yan Yang  ⁵, Li-Hua Zhang  ⁶, Xiu-Qin Lu  ⁷, Ying-Qing Yang  ⁸, Jin-Xia Lin  ⁹, Chun-Mei Zhang  ¹⁰, Li-Ping Luo  ¹¹, Dong-Hua Jiang  ¹², Shao-Hua Huang  ¹³, Xiu-Bi Huang  ¹⁴, Yue-Mei Zhan  ¹⁵, Wen-Zhu Xu  ¹⁶, Wei Han  ^{17   18}, Fu-Yuan Hong  ¹⁹ （Affiliations ¹ Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. lanne_huang@foxmail.com. ² Department of Blood Purification, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. ³ Department of Blood Purification, Renhe Hospital of Hubei Three Gorges University, Yichang, Hubei, China. ⁴ Department of Blood Purification, Xinjiang Changji Hui Autonomous Prefecture Hospital of Traditional Chinese Medicine, Changji, Xinjiang, China. ⁵ Department of Blood Purification, Pengyang People's Hospital of Ningxia Hui Autonomous Region, Pengyang, Ningxia, China. ⁶ Department of Blood Purification, Fuzhou First Hospital, Fuzhou, Fujian, China. ⁷ Department of Blood Purification, Fuzhou General Hospital, Fuzhou, Fujian, China. ⁸ Department of Blood Purification, Affiliated Hospital of Putian University, Putian, Fujian, China. ⁹ Department of Blood Purification, Quanzhou First Hospital, Quanzhou, Fujian, China. ¹⁰ Department of Blood Purification, Wuyishan Municipal Hospital, Wuyishan, Fujian, China. ¹¹ Department of Blood Purification, Nanping People's Hospital, Nanping, Fujian, China. ¹² Department of Blood Purification, Sanming Second Hospital, Sanming, Fujian, China. ¹³ Department of Blood Purification, Sanming First Hospital, Sanming, Fujian, China. ¹⁴ Department of Blood Purification, Zhangzhou Hospital, Zhangzhou, Fujian, China. ¹⁵ Department of Blood Purification, Longyan First Hospital, Longyan, Fujian, China. ¹⁶ Department of Blood Purification, Ningde Mindong Hospital, Mindong, Fujian, China. ¹⁷ Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. ¹⁸ Department of Blood Purification, Xiamen Zhongshan Hospital, Xiameng, Fujian, China. ¹⁹ Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, China. hongdoc@163.com.）

出处： Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2025

作者： Yanqin Xu MD^1,2;Yinxin Wu MD^1,2;Wanyin Deng MD¹;Xianbin Guo MD¹;Pingting Gao MD³;Shijie Yang MD¹;Yahua Chen MD⁴;Pinghong Zhou MD³;Wei Liang MD¹CA （¹Department of Digestive Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China;²Drs Xu and Wu contributed equally to this article.;³Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Affiliated with Fudan University, Shanghai, China;⁴Department of Gastroenterology, Affiliated Hospital of Putian University, Putian, China）

出处： Gastrointestinal Endoscopy 2025

摘要： Background and Aims Deep endotracheal intubation (DET) has been proposed to improve cervical esophageal endoscopic submucosal dissection (ESD) because ...

作者： Zhongdong Xie¹;Hanbin Lin²;Yuecheng Wu³;Yanan Yu⁴;Xintong Liu⁵;Yating Zheng⁶;Xiaojie Wang¹;Jiashu Wu⁷;Meifang Xu⁸;Yuting Han³;Qiongying Zhang⁹;Yu Deng¹;Lin Lin⁸;Yan Linzhu¹;Li Qingyun¹;Xinjian Lin³;Ying Huang¹;Pan Chi¹ （¹Department of Colorectal Surgery, Union Hospital, Fujian Medical University;²Central Laboratory, Affiliated Hospital of Putian University;³Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education;⁴Guilin Medical University;⁵Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University;⁶Department of Colorectal Surgery, The First Affiliated Hospital of Wenzhou Medical University;⁷Department of Science and Technology, The First Affiliated Hospital of Wenzhou Medical University;⁸Department of Pathology, Union Hospital, Fujian Medical University;⁹Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University）

出处： Cell Death and Disease 2025

摘要： Metastasis is a major challenge for colorectal cancer (CRC) treatment. In this study, we identified autophagy activation as a prognostic indicator in ...

作者： Jia Xu^1,2;Qiuhui Wang^1,3,2;Yishen Hu^1,3;Qingfeng Guo¹;Hu Zhu⁴;Honglin Wang⁵CA1;Hongxin Hu⁶CA2;Shouan Wang¹CA3;Jianbin Ye^1,3CA4 （¹Putian University, School of Basic Medicine Science, Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian City, Fujian Province 351100, China;²contribute equally to the study.;³Fujian Province, 351100, China Fujian Medical University, School of Pharmacy, Fuzhou City, Fujian Province 350004, China;⁴Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Engineering Research Center of Industrial Biocatalysis, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;⁵Department of Orthopedic Surgery, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing 402360, China;⁶The Affiliated Hospital of Putian University, Putian City, Fujian Province 351100, China）

出处： International Journal of Biological Macromolecules 2025

摘要： Scutellaria baicalensis extracts (SBACs), a herb that contains a variety of bioactive flavonoids like baicalein and baicalin, which impart antibacteri ...

作者： Jianxin Chen  ^{1   2}, Yuanbiao Zheng  ^{3   4}, Chaoyang Lin  ^{3   4} （Affiliations ¹ The First Department of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, 999 Dongzhen Road, Putian, 351100, Fujian, P.R. China. 28752338@qq.com. ² The School of Clinical Medicine, Fujian Medical University, Fuzhou, P.R. China. 28752338@qq.com. ³ The First Department of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, 999 Dongzhen Road, Putian, 351100, Fujian, P.R. China. ⁴ The School of Clinical Medicine, Fujian Medical University, Fuzhou, P.R. China.）

出处： Hernia : the journal of hernias and abdominal wall surgery 2025

关键词： Inguinal hernia;Meta-analysis;Open tension-free repair;Transabdominal preperitoneal (TAPP) repair.

作者： Jing Yang¹;Yue Deng¹;Zhonghui Chen²;Yue Lin¹;Dake Chen³CA1;Cuiying Lin¹CA2;Fang Luo¹;Zhenyu Lin¹CA3 （¹Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China;²Affiliated Hospital of Putian University, Putian University, Putian, Fujian 351100, PR China;³Department of Urology Surgery, Wenzhou No.3 Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang 325000, China）

出处： Microchemical Journal 2025

摘要： Detecting of hyaluronidase (HAase) activity is vital in oncology as it drives tumor invasion and metastasis by degrading hyaluronic acid (HA) in the e ...

作者： Jing Yang¹;Yue Deng¹;Zhonghui Chen²;Yue Lin¹;Dake Chen³CA1;Cuiying Lin¹CA2;Fang Luo¹;Zhenyu Lin¹CA3 （¹Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China;²Affiliated Hospital of Putian University, Putian University, Putian, Fujian 351100, PR China;³Department of Urology Surgery, Wenzhou No.3 Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang 325000, China）

出处： Microchemical Journal 2025

摘要： Detecting of hyaluronidase (HAase) activity is vital in oncology as it drives tumor invasion and metastasis by degrading hyaluronic acid (HA) in the e ...

作者： Shu-Han Xie¹;Shu-Han Xie²;Hui Xu¹;Hui Xu²;Hai Zhang³;Jin-Xin Xu⁴;Shi-Jie Huang⁵;Wen-Yi Liu⁶;Zi-Lu Tang⁷;Zi-Lu Tang⁸;Rong-Yu Xu⁷;Rong-Yu Xu⁸;Sun-Kui Ke⁴;Jin-Biao Xie⁵;Qing-Yi Feng⁹;Ming-Qiang Kang¹;Ming-Qiang Kang¹⁰;Ming-Qiang Kang¹¹;Ming-Qiang Kang¹²;Ming-Qiang Kang¹³ （¹Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China;²The Graduate School of Fujian Medical University, Fuzhou, Fujian, China;³Department of Thoracic Surgery, Gaozhou People’s Hospital, Gaozhou, Guangdong;China;⁴Department of Thoracic Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;⁵Department of Cardiothoracic Surgery, The Affiliated Hospital of Putian University, Putian, China;⁶Department of Thoracic Surgery, Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, China;⁷Department of Thoracic Surgery, Quanzhou First Hospital, Quanzhou, Fujian;China;⁸Department of Thoracic Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, China;⁹Department of Ultrasound, Gaozhou People’s Hospital, Gaozhou, Guangdong, China;¹⁰0Key Laboratory of Cardio-Thoracic Surgery(Fujian Medical University), Fujian Province University, Fuzhou, Fujian, China;¹¹1Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China;¹²2Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, Fujian, China;¹³3Clinical Research Center for Thoracic Tumors of Fujian Province, Fuzhou, Fujian, China）

出处： Frontiers in Immunology 2025

关键词： neoadjuvant chemoimmunotherapy;treatment response;habitat imaging;vision transformer;machine learning;tumor subregions

摘要： ObjectiveCurrent medical examinations and biomarkers struggle to assess the efficacy of chemoimmunotherapy (nICT) for locally advanced esophageal squa ...