作者： Yuanqing Cai^1,2,3;Hongxin Hu^1,2,4,3;Yang Chen^1,2,3;Jiayu Li^1,2;Chaofan Zhang^1,2;Xuhui Yuan^1,2;Wenbo Li^1,2;Changyu Huang⁵;Yiming Lin^1,2;Zeyu Zhang^1,2;Bin Yang⁶;Zida Huang^1,2CA1;Wenming Zhang^1,2CA2;Xinyu Fang^1,2CA3 （¹Department of Orthopaedic Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China;²Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China;³These authors contributed equally to this work.;⁴Department of Orthopaedics, Affiliated Hospital of Putian University, Putian, China;⁵Department of Orthopaedic Surgery, Quanzhou Orthopedic-traumatological Hospital, Quanzhou, China;⁶Department of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China）

出处： Drug Resistance Updates 2026

摘要： Aims In chronic osteomyelitis, the cortical bone serves as the primary site for long-term persistence of Staphylococcus aureus (S. aureus), the presen ...

作者： Jing Yang^1,2;Zhonghui Chen^3,2;Yue Lin¹;Cuiying Lin¹CA1;Fang Luo¹;Bin Qiu¹;Jian Wang¹;Zhenyu Lin¹CA2;Huixing Chen^4,5CA3 （¹Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fujian 350116, PR China;²J.Y. and Z.C. contributed equally to this work. The manuscript was written through the contributions of all authors. All authors have given approval to the final version of the manuscript;³Central Laboratory, Affiliated Hospital of Putian University, Putian University, Putian, Fujian 351100, PR China;⁴Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, PR China;⁵Fujian Medical University Cancer Center, Fuzhou, Fujian 350000, PR China）

出处： Sensors and Actuators B: Chemical 2026

摘要： Elevated hyaluronidase (HAase) concentration has been found in the urine samples of the patients with bladder cancer and development of simple but sen ...

作者： Bi-Xia Huang^1,2,3;Tao Zhang^1,3;Qing-Bin Dong¹;Peng-Xing Lin²;Yi Zhou²CA1;Xin-Shuo Chen^1,2CA2 （¹Department of Neurology, The Affiliated Hospital of Putian University, Putian, China;²The School of Clinical Medicine, Fujian Medical University, China;³These authors have contributed equally to this work.）

出处： Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2026

摘要： Iron oxide nanoparticles (IONPs) are widely applied in biomedicine and industry, yet their impact on early nervous system formation is poorly understo ...

作者： 赖越¹，林轩²，徐淼³，刘欢⁴，沈剑粦⁵，黄文华^1,6 （¹广东医科大学第一临床医学院；²莆田学院环境与生物工程学院；³福建医科大学基础医学院；⁴西南医科大学附属中医医院骨科；⁵莆田学院附属医院中心实验室；⁶南方医科大学基础医学院人体解剖学国家重点学科,广东省数字医学与生物力学重点实验室,广东省医学 3D 打印应用转化工程技术研究中心）

出处： 中国组织工程研究 2025

关键词： 骨质疏松；海洋中药；数据挖掘；网络药理学；分子对接

摘要： 背景：海洋中药为治疗骨质疏松提供了一种潜在有效且不易产生不良反应的方法。目的：应用数据挖掘和网络药理学方法分析并探讨中医临床治疗骨质疏松的用药规律及作用机制。方法：采用数据挖掘和网络药理学方法，对国家知识产权局批准的治疗骨质疏松的海洋中药专利处方进行用药模式和作用机制研究，并特别关注这些处方中的核心 ...

作者： 曾庆煌，魏凤芳，许金霞，郑丽平，林灵木，肖旭 （莆田学院附属医院儿科）

出处： 中国病原生物学杂志 2025

关键词： 癫痫；肠道菌群失衡；影响因素

摘要： 目的分析癫痫患儿肠道菌群失衡状况及影响因素。方法将本院2020年9月~2023年8月期间收治的96例癫痫患儿设为观察组,另选取同期92名健康儿童为对照组。根据肠道菌群是否失衡将观察组分为未失衡组(n=45)和失衡组(n=51)。癫痫患儿肠道菌群失衡的影响因素采用多因素Logistic回归分析。绍结果 ...

作者： Guohuan Chen^1,2;Bizhi Zheng²;Jinhe Cui¹CA1 （¹Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Putian University, Putian, China;²Department of Pulmonary and Critical Care Medicine, Putian Pulmonary Hospital, Putian, China）

出处： Human Heredity 2025

关键词： Asthma;Proteinase-activated receptor 2;F2RL1 gene;Single nucleotide polymorphism;Gene expression regulation;Case-control studies

摘要： Introduction: Asthma is a chronic respiratory disorder characterized by airway inflammation, hyperresponsiveness, and reversible airflow obstruction. ...

作者： Xiaomei Li¹;Huiyuan Xu¹;Ruoxi Chen¹;Xianzhi Huang¹;Zequan Lin¹;Shouan Wang¹;Lihong Han¹;Jinqiu Li²;Lihong Lin³;Yamei Qi³;Gang Song⁴;Conghua Song¹ （¹School of Basic Medicine, Putian University;²Central Laboratory, The Affiliated Hospital of Putian University;³Pharmaceutical and Medical Technology College, Putian University;⁴Cancer Research Center, School of Medicine, Xiamen University）

出处： Scientific Reports 2025

关键词： Astaxanthin;USP39;Β-catenin;Ubiquitination;Hepatocellular carcinoma;Proliferation

摘要： Although studies suggest that astaxanthin exerts anticancer effects through Wnt/β-catenin pathway, its therapeutic target remains unclear. The deubiqu ...

作者： Lianjie Ruan¹;Lianjie Ruan²;Dekai Lin²;Binqin Lin²;Qingqing Zhan²;Lili Zheng²;Dandan Lin²;Yaoning Zhuang²;Yiming Zeng¹ （¹Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Putian University, Putian, Fujian, China;²Department of Pneumology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China）

出处： Frontiers in Pharmacology 2025

关键词： inflammation;lung injury;carnosine;immune homeostasis;metabolomic profiling

摘要： BackgroundInflammatory lung injury is a common pathological feature of pneumonia caused by various infectious and non-infectious agents. However, meta ...

作者： Conghua Song¹;Huiyuan Xu²;Xiaomei Li²;Xiaomei Li³ （¹Gastrointestinal Endoscopy Center, The Affiliated Hospital of Putian University, Putian, Fujian, China;²School of Basic Medicine, Putian University, Putian, Fujian, China;³Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian University, Putian, Fujian, China）

出处： Frontiers in Medicine 2025

关键词： endoscopic mucosal resection (EMR);endoscopic submucosal dissection (ESD);submucosal injection;superficial gastrointestinal neoplasms;therapeutic endoscopy

摘要： Endoscopic submucosal dissection (ESD) is a widely used technique for en bloc resection of gastrointestinal neoplasms. However, it is technically dema ...

作者： Yao Chen¹, Jianhuang Huang¹, Quanming Zhou¹, Yuanbao Kang^{1   2} （Affiliations ¹ Department of Neurosurgery, Affiliated Hospital of Putian University, Putian, Fujian Province, China. ² Department of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian Province, China.）

出处： Medicine 2025

关键词： Mendelian randomization;causal relationship;intracranial aneurysms;periodontitis.

摘要： Previous studies have suggested an association between periodontitis and intracranial aneurysms (IAs). However, it remains unclear whether the associa ...