作者： Qian Yi¹;Qian Yi²;Qian Yi³;Zhenhan Deng⁴;Jiaji Yue¹;Jinglong He¹;Jianyi Xiong¹;Wei Sun¹;Weichao Sun¹;Weichao Sun⁵ （¹Department of Bone and Joint Surgery, Shenzhen Second People’s Hospital (The First Affiliated Hospital of Shenzhen University), Shenzhen, China;²Department of Orthopaedics, Affiliated Hospital of Putian University, Putian, China;³Department of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, China;⁴Department of Sports Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, China;⁵The Central Laboratory, Shenzhen Second People’s Hospital (The First Affiliated Hospital of Shenzhen University), Shenzhen, China）

出处： Frontiers in Cell and Developmental Biology 2022

关键词： RNA binding proteins;osteoarthritis;alternative splicing;mRNA stability;RNA metabolism

摘要： Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, ...

作者： Yan Huang ^{#  1}, Qian Yi ^{#  2   3}, Jianguo Feng  ⁴, Wei Xie  ⁵, Wei Sun  ⁶, Weichao Sun  ^{7   8} （Affiliations ¹ Department of Dermatology, Suining First People's Hospital, Suining, 629000, Sichuan, China. ² The Central Laboratory, Affiliated Hospital of Putian University, Putian, China. ³ Department of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, Sichuan, China. ⁴ Laboratory of Anesthesiology, Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. ⁵ Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, Guangdong, China. ⁶ Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, Guangdong, China. 414464705@qq.com. ⁷ Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, Guangdong, China. weichaosunshine@163.com. ⁸ The Central Laboratory, Shenzhen Second People' Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, Guangdong, China. weichaosunshine@163.com.）

出处： Human cell 2022

关键词： Apoptosis;HIF-1α;LincRNA-p21;Proliferation;Tumorigenesis;p53 pathway.

摘要： Long non-coding RNAs (lncRNAs) are a type of multifunctional endogenous RNA transcript. The dysregulation of lncRNAs is considered to play a role in t ...

作者： Shaorui Zheng  ^{1   2}, Cheng Wang  ³, Long Lin  ⁴, Shuwen Mu  ⁵, Haibing Liu  ⁶, Xiaofang Hu  ⁷, Xiangrong Chen  ⁸, Shousen Wang  ⁹ （Affiliations ¹ Fujian Medical University, Department of Neurosurgery, Fuzong Clinical Medical college, Fuzhou, China. ² Putian University, Department of Neurosurgery, Affiliated Hospital of Putian University, Putian, Fujian, China; zshaorui123@163.com. ³ The First Affiliated Hospital of Wannan Medical College, Department of Neurosurgery, Wuhu, Anhui, China; wangcheng@fjmu.edu.cn. ⁴ Fujian Medical University, Department of Neurosurgery, Fuzong Clinical Medical college, Fuzhou, Fujian, China; 1030829724@qq.com. ⁵ Fujian Medical University, Department of Neurosurgery, Fuzong Clinical Medical college, Fuzhou, Fujian, China; musw6778@126.com. ⁶ 900th Hospital of PLA, Department of Neurosurgery, Fuzhou, Fujian, China; lhb200196@sohu.com. ⁷ 900th Hospital of PLA, Department of Neurosurgery, Fuzhou, Fujian, China; huxiaofang0519@126.com. ⁸ Second Affiliated Hospital of Fujian Medical University, Department of Neurosurgery, Quanzhou, Fujian, China; rong281@126.com. ⁹ 900th Hospital of PLA, Department of Neurosurgery, Fuzhou, Fujian, China; wshsen@126.com.）

出处： Journal of neurotrauma 2022

关键词： BLOOD FLOW;BLOOD-BRAIN BARRIER DYSFUNCTION;INFLAMMATION;OXIDATIVE STRESS;TRAUMATIC BRAIN INJURY.

摘要： Secondary structural and functional abnormalities of the neurovascular unit are important pathological mechanisms following traumatic brain injury (TB ...

作者： Weidan Wu  ¹, Linlin Zheng  ¹ （Affiliation ¹ Oncology Department, The Affiliated Hospital of Putian University, Putian, China.）

出处： Evidence-based complementary and alternative medicine : eCAM 2022

摘要： Objective: Brain metastasis (BM) is associated with a high mortality in patients with breast cancer (BC). Nevertheless, the molecular mechanisms of BM ...

作者： Ben Liu  ¹, Wen Dong  ¹, Jie Sun  ¹, Ling-Hong Pan  ¹, Xue-Ying Cheng  ², Yong-Zhi Lun  ³ （Affiliations ¹ Pharmaceutical and Medical Technology College, Key Laboratory of Medical Microecology (Putian University), Fujian Province University. ² Department of Neurology, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China.E-mail:chengxueying2010@163.com. ³ Pharmaceutical and Medical Technology College, Key Laboratory of Medical Microecology (Putian University), Fujian Province University.E-mail: lunyz@163.com.）

出处： Zhongguo shi yan xue ye xue za zhi 2022

关键词： PI3K-Ⅲ;apoptosis;autophagy;leukemia.

摘要： Objective: To study the molecular mechanism of PI3K-Ⅲ like functional domain inducing programmed cell death of leukemia cell line K562. Methods: The p ...

作者： Hongxin Hu  ¹, Guoli Chen  ¹, Xianwei Wu  ¹, Mei Lin  ², Haibin Lin  ¹ （Affiliations ¹ Department of Orthopaedics, Affiliated Hospital of Putian University, Putian, China. ² Operating Room, Affiliated Hospital of Putian University, Putian, China.）

出处： Orthopaedic surgery 2022

关键词： Difficult-to-reduce;Finger reduction tool;Intertrochanteric fracture;Pre-drilling;Proximal femoral nail anti-rotation.

摘要： Objective: To investigate the feasibility of pre-drilling combined with a finger reduction tool for the reduction of difficult-to-reduce intertrochant ...

作者： Guoli Lin  ¹, Caizhi Dai  ¹, Kaizu Xu  ¹, Meifang Wu  ¹ （Affiliation ¹ Department of Cardiology, The Affiliated Hospital of Putian University, Putian University, Putian, Fujian, China (mainland).）

出处： Medical science monitor : international medical journal of experimental and clinical research 2022

摘要： BACKGROUND Atrial fibrillation (AF) is the most common arrhythmia and is associated with deleterious consequences. In addition to worsening a patient' ...

作者： Tingting Huang  ^{1   2}, Jiwei Li  ³, Xinli Liu  ¹, Bingbing Shi  ⁴, Shiqin Li  ⁵, Han-Xiang An  ¹ （Affiliations ¹ Department of Medical Oncology, Xiang'an Hospital of Xiamen University, Xiamen, China. ² Department of Medical Oncology, Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine, Xiamen, China. ³ Department of Respiratory, Critical Care and Sleep Medicine, Xiang'an Hospital of Xiamen University, Xiamen, China. ⁴ Department of Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, China. ⁵ Department of Gastroenterology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.）

出处： Frontiers in immunology 2022

关键词： SCF complex;difference;immune infiltration;pan-cancer;prognosis;ring-finger proteins.

摘要： Background: The SCF (Skp1-cullin-F-box proteins) complex is the largest family of E3 ubiquitin ligases that mediate multiple specific substrate protei ...

作者： Xi Chen  ¹, Meifang Wu  ² （Affiliations ¹ Department of Cardiology, Affiliated Hospital of Putian University, Fujian, China. ² Department of Cardiology, Affiliated Hospital of Putian University, Fujian, China. Electronic address: 646691205@qq.com.）

出处： The American journal of the medical sciences 2022

关键词： Ejection fraction;Heart failure;Recovered;Reverse remodeling.

摘要： Heart failure with reduced ejection fraction (HFrEF) is a prevalent kind of heart failure in which a significant amount of the ejection fraction can b ...

作者： Chenxing Jian  ^{1   2}, Zili Zhou  ³, Shen Guan  ⁴, Jianying Fang  ², Jinhuang Chen  ¹, Ning Zhao  ¹, Haijun Bao  ¹, Xianguo Li  ¹, Xukai Cheng  ¹, Wenzhong Zhu  ¹, Chunkang Yang  ⁴, Xiaogang Shu  ¹ （Affiliations ¹ Department of Gastrointestinal Surgery and Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ² Department of Minimally Invasive Surgery, Affiliated Hospital of Putian University, Teaching Hospital of Fujian Medical University, Putian, China. ³ Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. ⁴ Department of Gastrointestinal Surgical Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China.）

出处： Frontiers in surgery 2022

关键词： colorectal cancer;complications;incomplete ERAS protocol;propensity score-matched analysis;traditional care.

摘要： Background: The patients undergoing laparoscopic radical colorectomy in many Chinese hospitals do not achieve high compliance with the ERAS (enhanced ...